SCN3B and NFASC

Number of citations of the paper that reports this interaction (PMID 11470829)
35

Data Source:
HPRD (in vivo)

		SCN3B	NFASC
Gene Name		sodium channel, voltage gated, type III beta subunit	neurofascin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc	Intracellular Plasma Membrane Focal Adhesion Integral Component Of Membrane Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion
	Biological Process	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		1 interactors: NFASC	10 interactors: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR
Entrez ID		55800	23114
HPRD ID		10497	12372
Ensembl ID		ENSG00000166257	ENSG00000163531
Uniprot IDs		Q9NY72	B4DRH7 O94856
PDB IDs			3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Clustering Of Voltage-gated Sodium Channels Neuronal Ion Channel Clustering Protein Localization To Paranode Region Of Axon Protein Localization To Juxtaparanode Region Of Axon Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Neuron Maturation Myelin Assembly Transmission Of Nerve Impulse Peripheral Nervous System Development Cell-cell Junction Assembly Myelination Axon Ensheathment Cell Maturation Synapse Organization Cell Junction Assembly Cell-cell Junction Organization Axon Guidance	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuronal Action Potential Propagation Neuron Projection Development Nervous System Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Transmission Of Nerve Impulse Cell Development Response To External Stimulus Neurological System Process Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Multicellular Organismal Development Anatomical Structure Development Membrane Depolarization During Cardiac Muscle Cell Action Potential Anatomical Structure Morphogenesis Developmental Process Cell-cell Signaling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential Cell Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Monovalent Inorganic Cation Transport Central Nervous System Projection Neuron Axonogenesis Sodium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cell Migration Signaling
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