SCN3B and VAMP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCN3B	VAMP2
Description		sodium voltage-gated channel beta subunit 3	vesicle associated membrane protein 2
Image
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytosol Plasma Membrane Membrane Z Disc Monoatomic Ion Channel Complex	Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction	Exocytosis Vesicle Fusion Response To Glucose Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil	Botulinum toxin type B
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Response to citalopram or escitalopram in depression ( 27622933)	Chronotype ( 30696823) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Morning person ( 30696823) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		116 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARLN ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CCDC167 CDIPT CLCA4 CMTM5 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 FAM241B FAM3C FIS1 FKBP8 FXYD3 FXYD6 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LHFPL5 LPAR3 MAL2 MARCHF2 MGST3 MS4A13 NFASC NINJ2 NRM ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 PNLIPRP1 RHD RNF8 RTP2 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC61A1 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM203 TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB YIF1A YIPF4 YIPF6 ZFPL1	47 interacting genes: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNCA STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21
Entrez ID		55800	6844
HPRD ID		10497	01717
Ensembl ID		ENSG00000166257	ENSG00000220205
Uniprot IDs		Q9NY72	F8WCA0 P63027
PDB IDs		4L1D 7TJ8 7TJ9	3FIE 3FII 3RK2 3RK3 3RL0 7UDC 9CKX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Organelle Fusion Organelle Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Endomembrane System Vesicle Fusion SNARE Complex Assembly Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Intracellular Transport Vesicle Organization Establishment Of Localization In Cell Organelle Localization By Membrane Tethering Transmembrane Transport Golgi Membrane Membrane Docking Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Endoplasmic Reticulum Organization Monoatomic Ion Transmembrane Transporter Activity CDP-diacylglycerol Metabolic Process Mitochondrial Outer Membrane Lipid Metabolic Process Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Serine Import Into Mitochondrion Chemical Homeostasis Mitochondrial Membrane Lipid Biosynthetic Process Amino Acid Transmembrane Transport Neutral Amino Acid Transport Synaptic Vesicle Membrane Protein Transport Syntaxin Binding Establishment Of Protein Localization Monoatomic Ion Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Myelination Axon Ensheathment Establishment Of Protein Localization To Plasma Membrane	Organelle Localization By Membrane Tethering Membrane Docking Exocytosis SNARE Complex Secretion By Cell SNAP Receptor Activity Vesicle Docking Secretion Organelle Localization Vesicle Fusion SNARE Binding Organelle Membrane Fusion Membrane Fusion Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Vesicle Organization Organelle Fusion Synaptic Vesicle Exocytosis Syntaxin-1 Binding Membrane Organization Regulated Exocytosis Vesicle Docking Involved In Exocytosis Signal Release Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Establishment Of Localization In Cell Membrane Regulation Of Secretion By Cell Establishment Of Protein Localization Calcium-ion Regulated Exocytosis Regulation Of Secretion Intracellular Protein Localization Protein Transport Cellular Localization Vesicle-mediated Transport In Synapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Neurotransmitter Transport Presynapse Regulation Of Exocytosis Specific Granule Regulation Of Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Hormone Secretion Insulin Secretion Syntaxin Binding Regulation Of Biological Quality Cytoplasmic Vesicle Neuron Projection
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