SCN3B and VAMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCN3B	VAMP3
Description		sodium voltage-gated channel beta subunit 3	vesicle associated membrane protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytosol Plasma Membrane Membrane Z Disc Monoatomic Ion Channel Complex	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Response to citalopram or escitalopram in depression ( 27622933)	Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		116 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARLN ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CCDC167 CDIPT CLCA4 CMTM5 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 FAM241B FAM3C FIS1 FKBP8 FXYD3 FXYD6 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LHFPL5 LPAR3 MAL2 MARCHF2 MGST3 MS4A13 NFASC NINJ2 NRM ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 PNLIPRP1 RHD RNF8 RTP2 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC61A1 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM203 TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB YIF1A YIPF4 YIPF6 ZFPL1	63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR
Entrez ID		55800	9341
HPRD ID		10497	04711
Ensembl ID		ENSG00000166257	ENSG00000049245
Uniprot IDs		Q9NY72	Q15836 Q6FGG2
PDB IDs		4L1D 7TJ8 7TJ9
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Organelle Fusion Organelle Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Endomembrane System Vesicle Fusion SNARE Complex Assembly Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Intracellular Transport Vesicle Organization Establishment Of Localization In Cell Organelle Localization By Membrane Tethering Transmembrane Transport Golgi Membrane Membrane Docking Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Endoplasmic Reticulum Organization Monoatomic Ion Transmembrane Transporter Activity CDP-diacylglycerol Metabolic Process Mitochondrial Outer Membrane Lipid Metabolic Process Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Serine Import Into Mitochondrion Chemical Homeostasis Mitochondrial Membrane Lipid Biosynthetic Process Amino Acid Transmembrane Transport Neutral Amino Acid Transport Synaptic Vesicle Membrane Protein Transport Syntaxin Binding Establishment Of Protein Localization Monoatomic Ion Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Myelination Axon Ensheathment Establishment Of Protein Localization To Plasma Membrane	Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen
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