SCN3B and CYP4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCN3B	CYP4F2
Description		sodium voltage-gated channel beta subunit 3	cytochrome P450 family 4 subfamily F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytosol Plasma Membrane Membrane Z Disc Monoatomic Ion Channel Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Metal Ion Binding Leukotriene-B4 20-monooxygenase Activity Arachidonate Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity 20-hydroxy-leukotriene B4 Omega Oxidase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Long-chain Fatty Acid Omega-hydroxylase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Lipid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Xenobiotic Metabolic Process Blood Coagulation Regulation Of Blood Pressure Fatty Acid Omega-oxidation Arachidonate Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Response to citalopram or escitalopram in depression ( 27622933)	Acenocoumarol maintenance dosage ( 19578179) Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 19300499 20833655)
Interacting Genes		116 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARLN ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CCDC167 CDIPT CLCA4 CMTM5 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 FAM241B FAM3C FIS1 FKBP8 FXYD3 FXYD6 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LHFPL5 LPAR3 MAL2 MARCHF2 MGST3 MS4A13 NFASC NINJ2 NRM ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 PNLIPRP1 RHD RNF8 RTP2 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC61A1 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM203 TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB YIF1A YIPF4 YIPF6 ZFPL1	35 interacting genes: AQP6 CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I
Entrez ID		55800	8529
HPRD ID		10497	05112
Ensembl ID		ENSG00000166257	ENSG00000186115
Uniprot IDs		Q9NY72	P78329
PDB IDs		4L1D 7TJ8 7TJ9
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Organelle Fusion Organelle Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Endomembrane System Vesicle Fusion SNARE Complex Assembly Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Intracellular Transport Vesicle Organization Establishment Of Localization In Cell Organelle Localization By Membrane Tethering Transmembrane Transport Golgi Membrane Membrane Docking Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Endoplasmic Reticulum Organization Monoatomic Ion Transmembrane Transporter Activity CDP-diacylglycerol Metabolic Process Mitochondrial Outer Membrane Lipid Metabolic Process Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Serine Import Into Mitochondrion Chemical Homeostasis Mitochondrial Membrane Lipid Biosynthetic Process Amino Acid Transmembrane Transport Neutral Amino Acid Transport Synaptic Vesicle Membrane Protein Transport Syntaxin Binding Establishment Of Protein Localization Monoatomic Ion Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Myelination Axon Ensheathment Establishment Of Protein Localization To Plasma Membrane	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nuclear Membrane Reassembly Mitotic Nuclear Membrane Reassembly Nuclear Membrane Organization Membrane Assembly Organic Hydroxy Compound Transport
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