LIMS1 and RSU1

Number of citations of the paper that reports this interaction (PMID 15878342)
23

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LIMS1	RSU1
Gene Name		LIM and senescent cell antigen-like domains 1	Ras suppressor protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein Complex Perinuclear Region Of Cytoplasm	Cytosol Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding	Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Cell Junction Assembly Chordate Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Protein Heterooligomerization Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Signal Transduction Ras Protein Signal Transduction Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Junction Assembly Positive Regulation Of GTPase Activity Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions	Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Urinary albumin excretion ( 21355061)
Protein-Protein Interactions		12 interactors: EHMT2 HOXA1 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X	5 interactors: APP GSK3B HGS LIMS1 RAF1
Entrez ID		3987	6251
HPRD ID		03978	01551
Ensembl ID		ENSG00000169756	ENSG00000148484
Uniprot IDs		P48059	Q15404
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Cell Development Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Substrate Adhesion-dependent Cell Spreading Locomotion Regulation Of Cellular Process Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Artery Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Artery Development Embryonic Cranial Skeleton Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Size Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Kinase B Signaling Regulation Of Gene Expression Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Adhesion Cell Motility Regulation Of BMP Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Actin Filament-based Process Facial Nucleus Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Smooth Muscle Cell Chemotaxis Nerve Development Blastocyst Development	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Regulation Of Cell Differentiation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Axonogenesis Regulation Of ERBB Signaling Pathway Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Neuron Projection Morphogenesis Regulation Of Peptidyl-serine Phosphorylation Extrinsic Apoptotic Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Complex Assembly Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Innate Immune Response Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Negative Regulation Of Type B Pancreatic Cell Development Synaptic Growth At Neuromuscular Junction Superior Temporal Gyrus Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?