LIMS1 and FERMT3

Number of citations of the paper that reports this interaction (PubMedID 25086068)
64

Data Source:
BioGRID (pull down)

		LIMS1	FERMT3
Description		LIM zinc finger domain containing 1	FERM domain containing kindlin 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Perinuclear Region Of Cytoplasm Anchoring Junction	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding	Integrin Binding Protein Binding Lipid Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of DNA-templated Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Platelet degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Serum alkaline phosphatase levels ( 33547301)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)
Interacting Genes		47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587	11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15
Entrez ID		3987	83706
HPRD ID		03978	07440
Ensembl ID		ENSG00000169756	ENSG00000149781
Uniprot IDs		A0A8Q3WKI3 A0A8Q3WKJ2 A0A8Q3WKK6 A0A8Q3WKP0 F8WC86 P48059	F5H3I6 Q86UX7
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF 7D2S 7D2T 7D2U 7LT9	2YS3 6V97 6V9G 7C3M
Enriched GO Terms of Interacting Partners?		Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Cell-matrix Adhesion SMAD Binding Positive Regulation Of Cell Differentiation Metal Ion Binding Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Filament-based Process Integrin-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Detection Of Muscle Stretch Telethonin Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Cell Differentiation Structural Constituent Of Muscle Positive Regulation Of Stem Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Stress Fiber Assembly Regulation Of DNA-templated Transcription Integrin Activation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sarcomere Z Disc Positive Regulation Of Epithelial To Mesenchymal Transition Actinin Binding Positive Regulation Of Actin Filament Bundle Assembly Integrin Binding Cardiac Myofibril Assembly Regulation Of Actin Filament Organization Nucleus Anchoring Junction I-SMAD Binding Actin Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization	Anchoring Junction Focal Adhesion Regulation Of Spontaneous Synaptic Transmission Integrin Binding Cell Adhesion Regulation Of Neurotransmitter Uptake Cell-substrate Adhesion Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Adhesion Heterotypic Cell-cell Adhesion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Positive Regulation Of Intracellular Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substrate Adhesion-dependent Cell Spreading Myoblast Fate Specification Integrin Alpha7-beta1 Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex Visual Behavior Glial Cell Development Synaptic Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process
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