LIMS1 and LPXN

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LIMS1	LPXN
Gene Name		LIM and senescent cell antigen-like domains 1	leupaxin
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein Complex Perinuclear Region Of Cytoplasm	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding	Transcription Cofactor Activity Protein Binding Zinc Ion Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Cell Junction Assembly Chordate Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Protein Heterooligomerization Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640)
Protein-Protein Interactions		12 interactors: EHMT2 HOXA1 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X	23 interactors: HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN PHF21A PLEKHH2 PLEKHN1 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB ZNF175 ZNF426
Entrez ID		3987	9404
HPRD ID		03978	05651
Ensembl ID		ENSG00000169756	ENSG00000110031
Uniprot IDs		P48059	B7Z5P7 O60711
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q	1X3H
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Cell Development Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Substrate Adhesion-dependent Cell Spreading Locomotion Regulation Of Cellular Process Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Artery Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Artery Development Embryonic Cranial Skeleton Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Size Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Kinase B Signaling Regulation Of Gene Expression Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Adhesion Cell Motility Regulation Of BMP Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Actin Filament-based Process Facial Nucleus Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Smooth Muscle Cell Chemotaxis Nerve Development Blastocyst Development	Regulation Of Cellular Process RNA Biosynthetic Process Signal Complex Assembly RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression MAPK Cascade Gene Expression Transcription, DNA-templated Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Cellular Response To Organic Substance Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epithelial Cell Migration Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell-matrix Adhesion Ameboidal-type Cell Migration Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Gene Expression Positive Regulation Of Kinase Activity Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Positive Regulation Of MAP Kinase Activity Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Response To Organic Substance Regulation Of Phosphatidylinositol 3-kinase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Abducens Nerve Formation Optokinetic Behavior Hsp90 Deacetylation Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Cell-matrix Adhesion
Tagcloud ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Difference) ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Intersection) ?