LIMS1 and RBBP8

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LIMS1	RBBP8
Gene Name		LIM and senescent cell antigen-like domains 1	retinoblastoma binding protein 8
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Transcriptional Repressor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding	Single-stranded DNA Endodeoxyribonuclease Activity RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Damaged DNA Binding Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Cell Junction Assembly Chordate Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Protein Heterooligomerization Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic Blastocyst Hatching DNA Repair Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing G2 DNA Damage Checkpoint Cell Division Meiotic Cell Cycle
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions	Meiotic recombination
Drugs
Diseases
GWAS			Height ( 18391951) Intracranial aneurysm ( 20364137) Tuberculosis ( 20694014)
Protein-Protein Interactions		12 interactors: EHMT2 HOXA1 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X	34 interactors: ATM BARD1 BRCA1 CLU CTBP1 CTBP2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 LIMS1 LMO1 LMO2 LMO4 MAP2K4 MRE11A PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 WDYHV1
Entrez ID		3987	5932
HPRD ID		03978	04990
Ensembl ID		ENSG00000169756	ENSG00000101773
Uniprot IDs		P48059	Q99708
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q	2L4Z
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Cell Development Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Substrate Adhesion-dependent Cell Spreading Locomotion Regulation Of Cellular Process Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Artery Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Artery Development Embryonic Cranial Skeleton Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Size Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Kinase B Signaling Regulation Of Gene Expression Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Adhesion Cell Motility Regulation Of BMP Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Actin Filament-based Process Facial Nucleus Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Smooth Muscle Cell Chemotaxis Nerve Development Blastocyst Development	Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process G2 DNA Damage Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Cell Death Cell Cycle Checkpoint Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Cell Death Negative Regulation Of Gene Expression Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Protein Modification Process Telomere Maintenance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Immune System Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Difference) ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Intersection) ?