LIMS1 and MBIP

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid)

		LIMS1	MBIP
Description		LIM zinc finger domain containing 1	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Perinuclear Region Of Cytoplasm Anchoring Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Mitotic Spindle ATAC Complex
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of DNA-templated Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Embryonic Development Positive Regulation Of JNK Cascade Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Serum alkaline phosphatase levels ( 33547301)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997)
Interacting Genes		47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587	47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		3987	51562
HPRD ID		03978	14368
Ensembl ID		ENSG00000169756	ENSG00000151332
Uniprot IDs		A0A8Q3WKI3 A0A8Q3WKJ2 A0A8Q3WKK6 A0A8Q3WKP0 F8WC86 P48059	B2RCV0 Q9NS73
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF 7D2S 7D2T 7D2U 7LT9
Enriched GO Terms of Interacting Partners?		Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Cell-matrix Adhesion SMAD Binding Positive Regulation Of Cell Differentiation Metal Ion Binding Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Filament-based Process Integrin-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Detection Of Muscle Stretch Telethonin Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Cell Differentiation Structural Constituent Of Muscle Positive Regulation Of Stem Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Stress Fiber Assembly Regulation Of DNA-templated Transcription Integrin Activation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sarcomere Z Disc Positive Regulation Of Epithelial To Mesenchymal Transition Actinin Binding Positive Regulation Of Actin Filament Bundle Assembly Integrin Binding Cardiac Myofibril Assembly Regulation Of Actin Filament Organization Nucleus Anchoring Junction I-SMAD Binding Actin Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization	Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Pore Localization Endosome Organization Positive Regulation Of GTPase Activity Cytoplasm Organelle Organization Positive Regulation Of Hydrolase Activity
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