LIMS1 and MBIP

Number of citations of the paper that reports this interaction (PMID 19060904)
157

Data Source:
BioGRID (two hybrid)

		LIMS1	MBIP
Gene Name		LIM and senescent cell antigen-like domains 1	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Cell Junction Assembly Chordate Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Protein Heterooligomerization Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Chromatin Organization Histone H3 Acetylation
Pathways		Cell junction organization Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Cell-extracellular matrix interactions	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		12 interactors: EHMT2 HOXA1 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X	41 interactors: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 CSRP2BP DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		3987	51562
HPRD ID		03978	14368
Ensembl ID		ENSG00000169756	ENSG00000151332
Uniprot IDs		P48059	B2RCV0 Q9NS73
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Cell Development Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Substrate Adhesion-dependent Cell Spreading Locomotion Regulation Of Cellular Process Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Artery Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Artery Development Embryonic Cranial Skeleton Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Size Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Kinase B Signaling Regulation Of Gene Expression Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Adhesion Cell Motility Regulation Of BMP Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Actin Filament-based Process Facial Nucleus Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Smooth Muscle Cell Chemotaxis Nerve Development Blastocyst Development	Organelle Organization Membrane Organization Histone H3 Acetylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Phosphorylation Histone Acetylation Establishment Of Localization In Cell Cellular Localization G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Establishment Of Endothelial Barrier Mitotic Cell Cycle Internal Protein Amino Acid Acetylation Secretion By Cell Protein Acetylation Regulation Of Metabolic Process Intermediate Filament Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Exocyst Assembly Intermediate Filament-based Process Exocytosis Chromatin Modification Axon Cargo Transport Endothelial Cell Development
Tagcloud ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility
Tagcloud (Difference) ?		accumulate adaptor attribution biogenesis computational constitutes counterparts cytoskeleton disproportionate e2 endomitosis gata1 hemostatic implicate incompletely megakaryocyte mk mks morphologic panel pinch1 platelet powerful profiled representing successive terminally thrombopoiesis tubulin	advantage applicability beads bipy competition dt20 electroactive electrochemical electrodes facile immunoprecipitation labeled mercury oligonucleotide oligonucleotides ons os osmium oxoosmium p53con probes quantities stranded structurally subnanogram titration took unlabeled versatility
Tagcloud (Intersection) ?