RADIL and USP7

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RADIL	USP7
Gene Name		Ras association and DIL domains	ubiquitin specific peptidase 7 (herpes virus-associated)
Image
Gene Ontology Annotations	Cellular Component	Microtubule	Nucleus Cytosol PML Body
	Molecular Function		P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding
	Biological Process	Signal Transduction Multicellular Organismal Development Substrate Adhesion-dependent Cell Spreading	Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ASCC2 CEP76 FGFR3 GATA1 KRT31 LITAF MAGEA11 MED19 MRFAP1L1 RHOXF2 SFI1 USP7 YWHAB	85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423
Entrez ID		55698	7874
HPRD ID		07663	03950
Ensembl ID		ENSG00000157927	ENSG00000187555
Uniprot IDs		F5H6X3 Q96JH8	B7Z815 Q6U8A4 Q93009
PDB IDs		1UM1 3EC8	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Dephosphorylation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Metabolic Process Basophil Differentiation Eosinophil Fate Commitment G2/M Transition Of Mitotic Cell Cycle Eosinophil Differentiation Transcriptional Activation By Promoter-enhancer Looping Regulation Of Dephosphorylation Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Protein Dephosphorylation Alveolar Secondary Septum Development Negative Regulation Of Protein Transport Axonogenesis Involved In Innervation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Maintenance Of DNA Methylation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Chondrocyte Proliferation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Centriole Replication Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cellular Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Phosphorylation Cell Cycle Phase Transition	Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death
Tagcloud ?		adhesion adhesiveness associates concurrent dynamics effector effectors emerging focal gtpase influences inside integrin kif14 kinesin mediate microtubules migration negatively optimal pdz polarity rap rap1 reach regulates spreading tethering thereby	accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Difference) ?		adhesion adhesiveness associates concurrent dynamics effector effectors emerging focal gtpase influences inside integrin kif14 kinesin mediate microtubules migration negatively optimal pdz polarity rap rap1 reach regulates spreading tethering thereby	accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Intersection) ?