ACACB and PEX14

Number of citations: 104 (PubMedID 35044719)
Data Source: BioGRID (unspecified method)

		ACACB	PEX14
Name		acetyl-CoA carboxylase beta	peroxisomal biogenesis factor 14
Structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding
	Biological Process	Acetyl-CoA Metabolic Process Pentose-phosphate Shunt Purine Nucleotide Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Fatty Acid Oxidation Response To Nutrient Levels Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Oxidation D-glucose Import Lactic Acid Secretion Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Fatty Acid Homeostasis Positive Regulation Of Heart Growth Response To Caloric Restriction Tricarboxylic Acid Metabolic Process Intracellular Aspartate Homeostasis Intracellular Glutamate Homeostasis Energy Homeostasis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Malonyl-CoA Biosynthetic Process	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP)	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs		Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Haloxyfop-P	None
Diseases		None	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Fish- and plant-related diet ( 32066663 ) Invasive cervical cancer ( 33794208 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 )	Asthma ( 34103634 32296059 27182965 ) Blond vs. brown/black hair color ( 30531825 ) Breast cancer ( 29059683 27117709 23535729 23535733 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Breast size ( 27182965 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Facial morphology ( 31763980 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hand grip strength ( 29313844 ) Heel bone mineral density ( 30598549 ) LDL cholesterol ( 30275531 ) Male-pattern baldness ( 28196072 ) Metabolite levels ( 23823483 ) Optic nerve measurement (rim area) ( 20395239 ) Prostate cancer ( 25217961 ) Refractive error ( 32231278 ) Self-reported allergy ( 23817569 ) Total cholesterol levels ( 30275531 )
Interacting Genes		4 interacting genes: HLCS PEX14 PRKAA2 USP7	24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1
Entrez ID		32	5195
HPRD ID		07044	03477
Ensembl ID		ENSG00000076555	ENSG00000142655
Uniprot IDs		O00763	O75381
PDB IDs		2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN	2W84 2W85 4BXU 9GAG
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Modification Process Response To Nutrient Levels Negative Regulation Of TORC1 Signaling TORC1 Signaling Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Peroxisome Transport Along Microtubule Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of TOR Signaling TOR Signaling Response To Biotin Regulation Of TOR Signaling [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Biotin Metabolic Process Protein Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Oxidative Stress Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Positive Regulation Of Autophagy Protein Localization To Lipid Droplet Symbiont-mediated Disruption Of Host Cell PML Body Biotin Binding Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Hepatocyte Apoptotic Process Rhythmic Process Negative Regulation Of Tubulin Deacetylation Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Regulation Of Establishment Of Protein Localization To Telomere Cellular Response To Chemical Stress Lipid Droplet Disassembly Regulation Of Tubulin Deacetylation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Monoubiquitinated Protein Deubiquitination Regulation Of Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling Phosphatidylethanolamine Biosynthetic Process Response To Oxidative Stress Regulation Of Protein Deacetylation Nucleotide-activated Protein Kinase Complex Regulation Of Stress Granule Assembly DNA Alkylation Repair Protein Unfolding	Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding