ACACB

Gene Name		acetyl-CoA carboxylase beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Endomembrane System
	Molecular Function	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Biotin Binding Metal Ion Binding
	Biological Process	Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Positive Regulation Of Lipid Storage Response To Organic Cyclic Compound Positive Regulation Of Cellular Metabolic Process Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Oxidation Protein Homotetramerization Positive Regulation Of Heart Growth Malonyl-CoA Biosynthetic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism
Drugs		Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID
Diseases
GWAS
Protein-protein Interactions		2 interactors: HLCS PRKAA2
Entrez ID		32
HPRD ID		07044
Ensembl ID		ENSG00000076555
Uniprot IDs		O00763
PDB IDs		2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC
Enriched GO Terms of Interacting Partners?		Protein Biotinylation Histone Biotinylation Response To Biotin Histone Modification Response To Nutrient Levels Response To Extracellular Stimulus Monocarboxylic Acid Metabolic Process Chromatin Modification Carnitine Shuttle Carnitine Transmembrane Transport Chromatin Organization Regulation Of Energy Homeostasis Carnitine Transport Biotin Metabolic Process Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Response To Organonitrogen Compound Quaternary Ammonium Group Transport Histone-serine Phosphorylation Chromosome Organization Carboxylic Acid Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Organic Acid Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Anion Homeostasis Regulation Of TOR Signaling Fatty Acid Transport Ammonium Transport Response To External Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Fatty Acid Metabolic Process Water-soluble Vitamin Metabolic Process Regulation Of Circadian Rhythm Response To Vitamin Regulation Of Autophagy Vitamin Metabolic Process Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process Small Molecule Metabolic Process Peptidyl-serine Phosphorylation Sterol Metabolic Process
Tagcloud ?		acetyl allele apoe apolipoprotein carboxylase carrier coa databases diabetic epsilon2 epsilon3 exacerbation exhibiting gg hyperlipidaemia medline meta nephropathy ors peroxisome pooled ppargamma proliferator promotion rs1801282 rs2268388 science t2dn web