ACACB and HLCS

Number of citations of the paper that reports this interaction (PMID 20085763)
2

Data Source:
BioGRID (enzymatic study)

		ACACB	HLCS
Gene Name		acetyl-CoA carboxylase beta	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Endomembrane System	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Acetyl-CoA Carboxylase Activity Biotin Carboxylase Activity Protein Binding ATP Binding Biotin Binding Metal Ion Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Carnitine Shuttle Positive Regulation Of Lipid Storage Response To Organic Cyclic Compound Positive Regulation Of Cellular Metabolic Process Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Oxidation Protein Homotetramerization Positive Regulation Of Heart Growth Malonyl-CoA Biosynthetic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Cell Proliferation Protein Biotinylation Histone Modification Small Molecule Metabolic Process Response To Biotin Histone Biotinylation
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Import of palmitoyl-CoA into the mitochondrial matrix Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID	Biotin
Diseases
GWAS
Protein-Protein Interactions		2 interactors: HLCS PRKAA2	4 interactors: ACACB DDX52 POT1 SNX27
Entrez ID		32	3141
HPRD ID		07044	08360
Ensembl ID		ENSG00000076555	ENSG00000159267
Uniprot IDs		O00763	P50747
PDB IDs		2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC
Enriched GO Terms of Interacting Partners?		Protein Biotinylation Histone Biotinylation Response To Biotin Histone Modification Response To Nutrient Levels Response To Extracellular Stimulus Monocarboxylic Acid Metabolic Process Chromatin Modification Carnitine Shuttle Carnitine Transmembrane Transport Chromatin Organization Regulation Of Energy Homeostasis Carnitine Transport Biotin Metabolic Process Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Response To Organonitrogen Compound Quaternary Ammonium Group Transport Histone-serine Phosphorylation Chromosome Organization Carboxylic Acid Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Organic Acid Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Anion Homeostasis Regulation Of TOR Signaling Fatty Acid Transport Ammonium Transport Response To External Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Fatty Acid Metabolic Process Water-soluble Vitamin Metabolic Process Regulation Of Circadian Rhythm Response To Vitamin Regulation Of Autophagy Vitamin Metabolic Process Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process Small Molecule Metabolic Process Peptidyl-serine Phosphorylation Sterol Metabolic Process	Establishment Of Natural Killer Cell Polarity Positive Regulation Of DNA Strand Elongation Malonyl-CoA Biosynthetic Process Telomere Formation Via Telomerase Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Fatty Acid Oxidation Carnitine Shuttle Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Carnitine Transmembrane Transport Carnitine Transport Biotin Metabolic Process Regulation Of Telomerase Activity Fatty-acyl-CoA Biosynthetic Process Coenzyme A Biosynthetic Process Quaternary Ammonium Group Transport Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Acetyl-CoA Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Coenzyme A Metabolic Process Endosome To Lysosome Transport Regulation Of Fatty Acid Oxidation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Lipid Storage Positive Regulation Of Heart Growth Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Lysosomal Transport Regulation Of DNA Biosynthetic Process Positive Regulation Of Organ Growth Negative Regulation Of DNA Replication Regulation Of Lipid Storage Regulation Of Heart Growth Natural Killer Cell Activation Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of DNA Replication Telomere Maintenance
Tagcloud ?		acetyl allele apoe apolipoprotein carboxylase carrier coa databases diabetic epsilon2 epsilon3 exacerbation exhibiting gg hyperlipidaemia medline meta nephropathy ors peroxisome pooled ppargamma proliferator promotion rs1801282 rs2268388 science t2dn web	accumulated cholesterol copyright cyclodextrin derived effectively glycolipids hepatocyte hpgcd hpgcds hydroxypropyl impaired ipsc lysosomal niemann npc phenocopy pick pluripotent powerful progenitors prolonged protected reserved restore rights signature storage tools
Tagcloud (Difference) ?		acetyl allele apoe apolipoprotein carboxylase carrier coa databases diabetic epsilon2 epsilon3 exacerbation exhibiting gg hyperlipidaemia medline meta nephropathy ors peroxisome pooled ppargamma proliferator promotion rs1801282 rs2268388 science t2dn web	accumulated cholesterol copyright cyclodextrin derived effectively glycolipids hepatocyte hpgcd hpgcds hydroxypropyl impaired ipsc lysosomal niemann npc phenocopy pick pluripotent powerful progenitors prolonged protected reserved restore rights signature storage tools
Tagcloud (Intersection) ?