OTUD5 and ARPC3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		OTUD5	ARPC3
Gene Name		OTU deubiquitinase 5	actin related protein 2/3 complex, subunit 3, 21kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Proteolysis Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ARPC3 TP53 TRAF3 UBC	20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL
Entrez ID		55593	10094
HPRD ID		06488	09175
Ensembl ID		ENSG00000068308	ENSG00000111229
Uniprot IDs		G5E9D7 Q96G74	O15145
PDB IDs		3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?		Immune Response Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Immune System Process Positive Regulation Of Immune Response Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Innate Immune Response Regulation Of G1/S Transition Of Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Immune Response Notch Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune System Process DNA Damage Checkpoint Apoptotic Process Mitotic Cell Cycle Checkpoint Programmed Cell Death Positive Regulation Of Protein Complex Assembly	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process
Tagcloud ?		ablation abrogated accumulates cascade conversely defective demonstrating depleted deubiquitinase deubiquitination e16d e94d efficiently etoposide facilitate genotoxic greatly linking lys mediating pdcd5 programmed reintroducing rescued sequential stabilization substantially uncovered	aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Difference) ?		ablation abrogated accumulates cascade conversely defective demonstrating depleted deubiquitinase deubiquitination e16d e94d efficiently etoposide facilitate genotoxic greatly linking lys mediating pdcd5 programmed reintroducing rescued sequential stabilization substantially uncovered	aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Intersection) ?