OTUD5

Gene Name		OTU deubiquitinase 5
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Ubiquitin-specific Protease Activity
	Biological Process	Proteolysis Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: ARPC3 TP53 TRAF3 UBC
Entrez ID		55593
HPRD ID		06488
Ensembl ID		ENSG00000068308
Uniprot IDs		G5E9D7 Q96G74
PDB IDs		3PFY 3TMO 3TMP
Enriched GO Terms of Interacting Partners?		Immune Response Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Immune System Process Positive Regulation Of Immune Response Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Innate Immune Response Regulation Of G1/S Transition Of Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Immune Response Notch Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune System Process DNA Damage Checkpoint Apoptotic Process Mitotic Cell Cycle Checkpoint Programmed Cell Death Positive Regulation Of Protein Complex Assembly
Tagcloud ?		ablation abrogated accumulates cascade conversely defective demonstrating depleted deubiquitinase deubiquitination e16d e94d efficiently etoposide facilitate genotoxic greatly linking lys mediating pdcd5 programmed reintroducing rescued sequential stabilization substantially uncovered