OTUD5 and UBR5

Number of citations of the paper that reports this interaction (PubMedID 30508113)
53

Data Source:
BioGRID (pull down)

		OTUD5	UBR5
Description		OTU deubiquitinase 5	ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Proteolysis Neural Crest Cell Differentiation Protein Deubiquitination Cell Differentiation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Regulation Of Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Protein Polyubiquitination DNA Repair DNA Damage Response Response To Oxidative Stress Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Estrogen Receptor Signaling Pathway Heterochromatin Boundary Formation Protein K29-linked Ubiquitination Positive Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway Retinoic Acid Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Canonical Wnt Signaling Pathway Cytoplasm Protein Quality Control DNA Repair-dependent Chromatin Remodeling Protein Branched Polyubiquitination
Pathways		Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5	53 interacting genes: ACSL4 AKIRIN2 ATF3 BARD1 CDC20 CEBPA CIB1 CIP2A CSPP1 DYRK2 ERG ESR1 GSK3B INO80C KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NFIL3 NR1I2 NR3C1 NRL OTUD5 PAIP1 PAIP2 PCK1 PGR PPP1CA PTTG1 RARA RUVBL2 RXRA SATB1 SMAD2 SMARCB1 SOX2 STIP1 TCEA1 TOPBP1 TXNIP UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2J1 UBE2L3 UBE3A VDR
Entrez ID		55593	51366
HPRD ID		06488	06436
Ensembl ID		ENSG00000068308	ENSG00000104517
Uniprot IDs		Q96G74	O95071
PDB IDs		3PFY 3TMO 3TMP	1I2T 2QHO 3PT3 8BJA 8C06 8C07 8D4X 8E0Q 8EWI 8P82 8P83
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex Ubiquitin Protein Ligase Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex DNA-templated Transcription 5'-3' RNA Polymerase Activity MRNA Transcription RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Protein Tag Activity Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus DNA Binding Nucleoplasm Macromolecule Biosynthetic Process RNA Binding MRNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Growth Cone Leading Edge Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription By RNA Polymerase II Interferon-mediated Signaling Pathway Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Heterochromatin Boundary Formation Regulation Of DNA-templated Transcription Initiation Regulation Of Proteolysis Nucleotidyltransferase Activity Ribonucleoside Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Site Of Double-strand Break Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Circadian Rhythm Positive Regulation Of Thymocyte Apoptotic Process	Positive Regulation Of Metabolic Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Chromatin Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Response To Lipid Protein K48-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Cellular Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Modification Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Proteolysis
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