OTUD5 and PDCD5

Number of citations of the paper that reports this interaction (PubMedID 25499082)
0

Data Source:
BioGRID (imaging technique, two hybrid, pull down)

		OTUD5	PDCD5
Description		OTU deubiquitinase 5	programmed cell death 5
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding
	Biological Process	Negative Regulation Of Cytokine Production Proteolysis Neural Crest Cell Differentiation Protein Deubiquitination Cell Differentiation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Regulation Of Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Apoptotic Process Positive Regulation Of Gene Expression Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Protein Folding
Pathways		Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Glycated hemoglobin levels ( 34059833) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 32888494) Red cell distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 33272962)
Interacting Genes		12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5	16 interacting genes: ACP5 CDC42 CEBPA CEP126 EEF1G KAT5 KDM1A LRIF1 NUDT3 OTUD5 PICK1 RAD18 TRIM35 UBE2D3 UTP14A VHL
Entrez ID		55593	9141
HPRD ID		06488	06843
Ensembl ID		ENSG00000068308	ENSG00000105185
Uniprot IDs		Q96G74	O14737
PDB IDs		3PFY 3TMO 3TMP	1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex Ubiquitin Protein Ligase Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex DNA-templated Transcription 5'-3' RNA Polymerase Activity MRNA Transcription RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Protein Tag Activity Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus DNA Binding Nucleoplasm Macromolecule Biosynthetic Process RNA Binding MRNA Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Growth Cone Leading Edge Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription Initiation By RNA Polymerase II Transcription By RNA Polymerase II Interferon-mediated Signaling Pathway Promoter-specific Chromatin Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Heterochromatin Boundary Formation Regulation Of DNA-templated Transcription Initiation Regulation Of Proteolysis Nucleotidyltransferase Activity Ribonucleoside Binding Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Site Of Double-strand Break Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Circadian Rhythm Positive Regulation Of Thymocyte Apoptotic Process	Protein Modification Process DNA-binding Transcription Factor Binding Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Superoxide Anion Generation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Macrophage Differentiation Neuron Projection Organization Ubiquitin Protein Ligase Activity Dendritic Spine Organization Postsynapse Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Gamma-glutamyl Carboxylase Activity Histone H2AK5 Acetyltransferase Activity DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Chromosome Segregation Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Rad6-Rad18 Complex Post-translational Protein Modification Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process GBD Domain Binding Storage Vacuole Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Vitamin Binding Negative Regulation Of Bone Development Protein Monoubiquitination Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Cell Cycle Process Protein Autoubiquitination Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Cycle CHOP-C/EBP Complex Cellular Response To Stress
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