SOX6 and SUMO3

Number of citations of the paper that reports this interaction (PMID 16442531)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SOX6	SUMO3
Gene Name		SRY (sex determining region Y)-box 6	small ubiquitin-like modifier 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Protein Binding SUMO Transferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Gene Silencing Oligodendrocyte Cell Fate Specification Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Astrocyte Differentiation Erythrocyte Development Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways			SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982) Capecitabine sensitivity ( 22864933) Obesity and osteoporosis ( 19714249) Wrist bone mass ( 21104366)
Protein-Protein Interactions		12 interactors: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2J1 ZNF184	53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM
Entrez ID		55553	6612
HPRD ID		06267	03754
Ensembl ID		ENSG00000110693	ENSG00000184900
Uniprot IDs		P35712	B4DUW4 P55854
PDB IDs			1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Cellular Protein Modification Process Peptidyl-lysine Modification Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Peptidyl-amino Acid Modification Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Ubiquitination PML Body Organization Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Timing Of Neuron Differentiation Protein Localization To Nuclear Pore Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Chromatin Binding Regulation Of Mesenchymal Stem Cell Differentiation Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis Protein Localization To Nuclear Envelope Negative Regulation Of Double-strand Break Repair Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Response To Transforming Growth Factor Beta Negative Regulation Of DNA Repair	Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Difference) ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Intersection) ?