SOX6 and SOX5

Number of citations of the paper that reports this interaction (PMID 9755172)
149

Data Source:
HPRD (in vitro)

		SOX6	SOX5
Gene Name		SRY (sex determining region Y)-box 6	SRY (sex determining region Y)-box 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Gene Silencing Oligodendrocyte Cell Fate Specification Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Astrocyte Differentiation Erythrocyte Development Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Central Nervous System Neuron Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Oligodendrocyte Differentiation Cartilage Development Regulation Of Timing Of Neuron Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982) Capecitabine sensitivity ( 22864933) Obesity and osteoporosis ( 19714249) Wrist bone mass ( 21104366)	AIDS ( 19754311) Non-obstructive azoospermia ( 22197933) PR interval ( 20062060) Response to antipsychotic treatment ( 20195266) Response to statin therapy ( 20339536) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		12 interactors: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2J1 ZNF184	26 interactors: AES APP ARID5A CBX8 CDC23 CDC25A CDK6 CRX FAM46B FTH1 KAT5 KIFC3 LMO1 LMO2 MED27 MORN3 PRR20A RPS2 SMAD1 SMAD5 SMAD7 SOX6 SUMO1P1 TTC1 UQCRFS1 ZNF581
Entrez ID		55553	6660
HPRD ID		06267	18086
Ensembl ID		ENSG00000110693	ENSG00000134532
Uniprot IDs		P35712	P35711 T2CYZ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Cellular Protein Modification Process Peptidyl-lysine Modification Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Peptidyl-amino Acid Modification Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Ubiquitination PML Body Organization Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Timing Of Neuron Differentiation Protein Localization To Nuclear Pore Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Chromatin Binding Regulation Of Mesenchymal Stem Cell Differentiation Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis Protein Localization To Nuclear Envelope Negative Regulation Of Double-strand Break Repair Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Response To Transforming Growth Factor Beta Negative Regulation Of DNA Repair	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Osteoblast Fate Commitment Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cartilage Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process BMP Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Connective Tissue Development Transcription From RNA Polymerase II Promoter Metabolic Process Skeletal System Development Negative Regulation Of Biosynthetic Process Organ Development Cellular Response To BMP Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development
Tagcloud ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered
Tagcloud (Difference) ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	aberrantly abrogated alcian atdc5 blue box chondrocyte chondrogenesis chondrogenic clonal delayed determining differentiating diminish drastic evidenced fate hypertrophic l lineage mobility osteoarthritic overexpressing progress proteoglycan retroviral runx2 unaltered
Tagcloud (Intersection) ?