SOX6 and CENPK

Number of citations of the paper that reports this interaction (PMID 10996314)
3

Data Source:
HPRD (two hybrid, in vitro)

		SOX6	CENPK
Gene Name		SRY (sex determining region Y)-box 6	centromere protein K
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Condensed Chromosome Kinetochore Nucleoplasm Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Gene Silencing Oligodendrocyte Cell Fate Specification Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Astrocyte Differentiation Erythrocyte Development Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mesenchymal Stem Cell Differentiation	Mitotic Cell Cycle Nucleosome Assembly CENP-A Containing Nucleosome Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982) Capecitabine sensitivity ( 22864933) Obesity and osteoporosis ( 19714249) Wrist bone mass ( 21104366)
Protein-Protein Interactions		12 interactors: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2J1 ZNF184	5 interactors: AP1G2 CENPH MRFAP1L1 PCBD2 SOX6
Entrez ID		55553	64105
HPRD ID		06267	13323
Ensembl ID		ENSG00000110693	ENSG00000123219
Uniprot IDs		P35712	Q9BS16
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Cellular Protein Modification Process Peptidyl-lysine Modification Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Peptidyl-amino Acid Modification Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Histone Ubiquitination PML Body Organization Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Timing Of Neuron Differentiation Protein Localization To Nuclear Pore Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Chromatin Binding Regulation Of Mesenchymal Stem Cell Differentiation Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis Protein Localization To Nuclear Envelope Negative Regulation Of Double-strand Break Repair Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Response To Transforming Growth Factor Beta Negative Regulation Of DNA Repair See more	Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Mesenchymal Stem Cell Differentiation Oligodendrocyte Cell Fate Specification Tetrahydrobiopterin Biosynthetic Process
Tagcloud ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	anaemia anaemic appearing cdca8 cdkn2d characterise claudin claudins cldn13 cldn4 congolense e2f2 enucleation erythroblast erythropoiesis erythropoietic gypa haematopoietic neighbour ordinately partitioning phylogenetically polarisation rhd tight tmcc2 trim10 trypanosoma unreported
Tagcloud (Difference) ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation epb41l1 erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sry udp xp22 xq26	anaemia anaemic appearing cdca8 cdkn2d characterise claudin claudins cldn13 cldn4 congolense e2f2 enucleation erythroblast erythropoiesis erythropoietic gypa haematopoietic neighbour ordinately partitioning phylogenetically polarisation rhd tight tmcc2 trim10 trypanosoma unreported
Tagcloud (Intersection) ?