STRADB and NEB

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		STRADB	NEB
Description		STE20 related adaptor beta	nebulin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Aggresome Serine/threonine Protein Kinase Complex	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	Cell Morphogenesis Protein Phosphorylation Protein Export From Nucleus JNK Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly
Pathways		Energy dependent regulation of mTOR by LKB1-AMPK	Striated Muscle Contraction
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS			Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		8 interacting genes: CAB39 GRB2 MAP3K7 NEB STK11 TRAF6 UBC XIAP	25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2
Entrez ID		55437	4703
HPRD ID		09546	01196
Ensembl ID		ENSG00000082146	ENSG00000183091
Uniprot IDs		Q9C0K7	P20929 Q05C45 Q96MF8
PDB IDs			1ARK 1NEB 6Y17
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Binding Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical NF-kappaB Signal Transduction Interleukin-17A-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Anoikis Positive Regulation Of JUN Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway T Cell Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Modification Process DNA Damage Response Regulation Of Type I Interferon Production Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Serine/threonine Protein Kinase Complex Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway P38MAPK Cascade Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Cellular Response To Stress Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-2 Production Activation Of Innate Immune Response Activation Of Protein Kinase Activity Regulation Of T Cell Cytokine Production Protein Kinase Activator Activity Toll-like Receptor 4 Signaling Pathway	Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly
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