STRADB and CAB39

Number of citations of the paper that reports this interaction (PMID 14676191)
42

Data Source:
HPRD (in vivo)

		STRADB	CAB39
Gene Name		STE20-related kinase adaptor beta	calcium binding protein 39
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Extracellular Vesicular Exosome Serine/threonine Protein Kinase Complex
	Molecular Function	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity Protein Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Mitotic Cell Cycle Cell Morphogenesis Protein Phosphorylation Protein Export From Nucleus Cell Cycle Arrest JNK Cascade Insulin Receptor Signaling Pathway Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cell Cycle Arrest Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Heterooligomerization Cellular Hypotonic Response Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Insulin receptor signalling cascade IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CAB39 GRB2 MAP3K7 STK11 TRAF6 XIAP	4 interactors: PRKAA1 STK11 STRADA STRADB
Entrez ID		55437	51719
HPRD ID		09546	10091
Ensembl ID		ENSG00000082146	ENSG00000135932
Uniprot IDs		Q9C0K7	A8K8L7 Q9Y376
PDB IDs			1UPK 1UPL 2WTK 3GNI 4FZA 4FZD 4FZF
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Activation Of Protein Kinase Activity Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Phosphorylation Protein Heterooligomerization Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Transferase Activity Insulin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Cytokine Production Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Regulation Of Protein Kinase Activity Cellular Response To Insulin Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Cellular Response To Organic Substance Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Interleukin-2 Production	Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Activation Of Protein Kinase Activity Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Cell Cycle Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Peptide Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Hormone Cell Cycle Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Protein Phosphorylation Cell Cycle Protein Export From Nucleus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Nuclear Export Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation TCR Signalosome Assembly Protein Heterooligomerization Response To UV Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?			alterative apical becomes convoluted cotransporter dct dct1 displaced displaying exclusive hyperphosphorylated hypotension m025alpha medulla mo25alpha modestly ncc nkcc2 osr1 paralleled punctate redistributes spak spak2 sps ste20 thiazide tubule wnk1
Tagcloud (Difference) ?			alterative apical becomes convoluted cotransporter dct dct1 displaced displaying exclusive hyperphosphorylated hypotension m025alpha medulla mo25alpha modestly ncc nkcc2 osr1 paralleled punctate redistributes spak spak2 sps ste20 thiazide tubule wnk1
Tagcloud (Intersection) ?