CASP2 and NLRP1

Number of citations of the paper that reports this interaction (PubMedID 11076957)
0

Data Source:
HPRD (in vivo)

		CASP2	NLRP1
Description		caspase 2	NLR family pyrin domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding	Nucleotide Binding Double-stranded DNA Binding Double-stranded RNA Binding Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity
	Biological Process	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Maturation Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Programmed Cell Death Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly
Pathways		NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases	The NLRP1 inflammasome
Drugs
Diseases
GWAS			Migraine ( 27322543)
Interacting Genes		32 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MAPT MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I	10 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 MAPK14 NOD1 PYCARD
Entrez ID		835	22861
HPRD ID		02800	07364
Ensembl ID		ENSG00000106144	ENSG00000091592
Uniprot IDs		A0A087WYM1 A0A0S2Z3H1 P42575	Q9C000
PDB IDs		1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD 6Y8B 6Y8D	1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6X6C 6XKK 7WGE 8ZGD
Enriched GO Terms of Interacting Partners?		Death Receptor Binding Cell Death Programmed Cell Death Apoptotic Process Cytosol Cytoplasm Regulation Of Apoptotic Process Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Effector Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death-inducing Signaling Complex Signal Transduction In Response To DNA Damage Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding Pyroptotic Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Nucleus Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Proteolysis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Enzyme Binding Intracellular Signal Transduction DNA Damage Response Response To Stress Endopeptidase Complex Regulation Of Protein-containing Complex Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Protein Polymerization Cellular Response To Staurosporine Regulation Of Metabolic Process	Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Regulation Of Programmed Cell Death NLRP1 Inflammasome Complex Cellular Response To Stress Apoptotic Signaling Pathway Intracellular Signal Transduction Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Neuron Apoptotic Process Identical Protein Binding Protein Maturation Cysteine-type Peptidase Activity Signal Transduction Apoptosome Dendritic Cell Apoptotic Process AIM2 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Response To Virus Response To External Biotic Stimulus DNA Damage Response Pyroptotic Inflammatory Response Response To Stress Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Response To Mechanical Stimulus BH3 Domain Binding Positive Regulation Of Interleukin-1 Beta Production Response To Cytokine Positive Regulation Of Neuron Apoptotic Process Response To Peptide Osmosensory Signaling Pathway Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Cellular Response To Mechanical Stimulus Cytosol Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Response To Other Organism Cysteine-type Endopeptidase Activator Activity
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