CASP2 and GOLGA3

Number of citations of the paper that reports this interaction (PubMedID 10791974)
59

Data Source:
HPRD (in vitro, in vivo)

		CASP2	GOLGA3
Description		caspase 2	golgin A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding	Protein Binding Cadherin Binding
	Biological Process	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Maturation Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways		NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases	RND2 GTPase cycle
Drugs
Diseases
GWAS			Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Body mass index ( 28552196) Immune response to smallpox vaccine (IL-6) ( 22542470) Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		32 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MAPT MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I	10 interacting genes: ATXN7 CASP2 CASP3 CASP7 FXR1 GOLGA7 GOPC KCNJ1 OLIG2 TSNAX
Entrez ID		835	2802
HPRD ID		02800	03990
Ensembl ID		ENSG00000106144	ENSG00000090615
Uniprot IDs		A0A087WYM1 A0A0S2Z3H1 P42575	A0A8I5KWY9 Q08378
PDB IDs		1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD 6Y8B 6Y8D
Enriched GO Terms of Interacting Partners?		Death Receptor Binding Cell Death Programmed Cell Death Apoptotic Process Cytosol Cytoplasm Regulation Of Apoptotic Process Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Effector Domain Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death-inducing Signaling Complex Signal Transduction In Response To DNA Damage Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding Pyroptotic Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Nucleus Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Proteolysis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Enzyme Binding Intracellular Signal Transduction DNA Damage Response Response To Stress Endopeptidase Complex Regulation Of Protein-containing Complex Assembly Positive Regulation Of Signal Transduction Positive Regulation Of Protein Polymerization Cellular Response To Staurosporine Regulation Of Metabolic Process	Execution Phase Of Apoptosis Cellular Response To Staurosporine Luteolysis Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Protein Poly-ADP-ribosylation Aspartic-type Endopeptidase Activity Cysteine-type Peptidase Activity Ovulation Cycle Process Protein Processing Cellular Response To Alkaloid Leukocyte Apoptotic Process Pyroptotic Inflammatory Response Mannose To Fructose-6-phosphate Catabolic Process Mannose-6-phosphate Isomerase Activity Negative Regulation Of Anion Channel Activity
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