CASP2 and MZB1

Number of citations of the paper that reports this interaction (PMID 11972030)
19

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CASP2	MZB1
Gene Name		caspase 2, apoptosis-related cysteine peptidase	marginal zone B and B1 cell-specific protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane	Extracellular Region Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Protein Binding
	Biological Process	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Immunoglobulin Biosynthetic Process Apoptotic Process Positive Regulation Of Cell Proliferation Regulation Of B Cell Proliferation Integrin Activation Regulation Of Cell Proliferation Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway p75 NTR receptor-mediated signalling NADE modulates death signalling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ADCYAP1 BID BIRC2 CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I	3 interactors: CASP2 CASP9 MAPK6
Entrez ID		835	51237
HPRD ID		02800	17815
Ensembl ID		ENSG00000106144	ENSG00000170476
Uniprot IDs		C9JRR9 D3DXD8 D3DXD9 P42575	B3KQ72 Q8WU39
PDB IDs		1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
Enriched GO Terms of Interacting Partners?		Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Response To Stress Signaling Positive Regulation Of Catalytic Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Signal Transduction Viral Process Cell Communication Positive Regulation Of Hydrolase Activity Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Execution Phase Of Apoptosis Positive Regulation Of Cell Death Response To Stimulus Glial Cell Apoptotic Process Protein Metabolic Process Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Death Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Protein Processing Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Intracellular Signal Transduction Aging Luteolysis Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Glial Cell Apoptotic Process Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Ectopic Germ Cell Programmed Cell Death Response To Cobalt Ion Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Formation Platelet Morphogenesis Cellular Response To DNA Damage Stimulus Cellular Response To Dexamethasone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Dexamethasone Apoptotic Process Developmental Programmed Cell Death Programmed Cell Death Cell Death Death Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Neural Retina Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Response To Antibiotic Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV
Tagcloud ?		amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized	associates biosynthesis block cochaperone conditional cre enables fl genotoxic germline gp96 grp94 hsp90b1 humoral immunoglobulin impairs injections integrin lymphopoiesis mb1 micro microhcs naturally perp1 proper recombinase tunicamycin unmasks whereby
Tagcloud (Difference) ?		amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized	associates biosynthesis block cochaperone conditional cre enables fl genotoxic germline gp96 grp94 hsp90b1 humoral immunoglobulin impairs injections integrin lymphopoiesis mb1 micro microhcs naturally perp1 proper recombinase tunicamycin unmasks whereby
Tagcloud (Intersection) ?