RFLNA and FDFT1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RFLNA	FDFT1
Description		refilin A	farnesyl-diphosphate farnesyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Bundle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Filamin Binding	Catalytic Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding Squalene Synthase [NAD(P)H] Activity
	Biological Process	Skeletal System Morphogenesis Regulation Of Chondrocyte Development Negative Regulation Of Chondrocyte Development Actin Filament Bundle Organization Negative Regulation Of Bone Mineralization Involved In Bone Maturation	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process
Pathways			Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs			TAK-475
Diseases
GWAS		Hallux valgus ( 32131869) Optic cup area ( 31798171) Osteoarthrosis (time to event) ( 32589924) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)	A body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: FBXW7 FDFT1 FLNA	25 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35H1 TLCD4 TMEM43 TMX2
Entrez ID		144347	2222
HPRD ID		14066	01694
Ensembl ID		ENSG00000178882	ENSG00000079459
Uniprot IDs		Q6ZTI6	A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs			1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5 8WTQ 8WTR
Enriched GO Terms of Interacting Partners?		Squalene Synthase [NAD(P)H] Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Farnesyl Diphosphate Metabolic Process Glycoprotein Ib-IX-V Complex Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Protein Localization To Bicellular Tight Junction Protein Stabilization Fc-gamma Receptor I Complex Binding Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Formation Of Radial Glial Scaffolds Tubulin Deacetylation Negative Regulation Of Protein Catabolic Process Myb Complex Establishment Of Sertoli Cell Barrier Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Ubiquitin Recycling Phosphothreonine Residue Binding Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Osteoclast Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Translation Release Factor Activity Translation Release Factor Activity, Codon Specific Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Blood Coagulation, Intrinsic Pathway Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Establishment Of Protein Localization Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Osteoclast Development Negative Regulation Of Transcription By RNA Polymerase I Regulation Of SREBP Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Regulation Of Protein Catabolic Process Protein Deacetylation Regulation Of Protein Stability Negative Regulation Of Catabolic Process Translational Termination Actin Crosslink Formation Negative Regulation Of Triglyceride Metabolic Process Ribosomal Large Subunit Binding Positive Regulation Of Neuron Migration Regulation Of Hepatocyte Proliferation Apical Dendrite Sertoli Cell Development Protein Localization To Cell-cell Junction Regulation Of Triglyceride Biosynthetic Process	Membrane Monoatomic Anion Channel Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Identical Protein Binding
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