ZNRF1 and ATP1A1

Number of citations of the paper that reports this interaction (PubMedID 22797923)
45

Data Source:
BioGRID (enzymatic study)

		ZNRF1	ATP1A1
Description		zinc and ring finger 1	ATPase Na+/K+ transporting subunit alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Synapse	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Cell Projection Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding P-type Potassium Transmembrane Transporter Activity Phosphatase Activity ATP Hydrolysis Activity Potassium Ion Binding Sodium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding Steroid Hormone Binding
	Biological Process	Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Osmosensory Signaling Pathway Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Monoatomic Cation Homeostasis Intracellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Heart Contraction Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Coffee consumption ( 29367735) HDL cholesterol levels in HIV infection ( 33109212) Hip index ( 34021172) Macular thickness ( 30535121)
Interacting Genes		14 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2V1 UBE2V2 UBE2W UBXN7	21 interacting genes: A2M ADD1 CEBPA CFL1 EGFR EZH2 FNDC3B FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA RNF10 SNAPIN TPT1 ZNRF1 ZNRF2
Entrez ID		84937	476
HPRD ID		15893	01662
Ensembl ID		ENSG00000186187	ENSG00000163399
Uniprot IDs		Q8ND25	P05023
PDB IDs		5YWR	7E1Z 7E20 7E21
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Macromolecule Metabolic Process Transferase Activity Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Protein K63-linked Ubiquitination Nucleus Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Protein K6-linked Ubiquitination DNA Metabolic Process DNA Damage Response Postreplication Repair Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination	Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Response To Epidermal Growth Factor Regulation Of Transport Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Autophagosome-lysosome Fusion ERBB2 Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Interleukin-34-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Sodium Channel Regulator Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Cell Population Proliferation Positive Regulation Of Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Developmental Process Regulation Of Golgi Inheritance Regulation Of Sodium Ion Transmembrane Transport Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Cellular Component Organization Intracellular Chemical Homeostasis Regulation Of Protein Metabolic Process Chemical Homeostasis Positive Regulation Of Cell Motility Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Sodium Ion Transport Positive Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Sodium:potassium-exchanging ATPase Complex Regulation Of Sodium Ion Transport Homeostatic Process Cellular Homeostasis Caveola ERBB Signaling Pathway Negative Regulation Of Cell Differentiation Focal Adhesion Morphogenesis Of An Epithelial Fold Regulation Of Cellular PH MAP Kinase Activity Regulation Of Golgi Organization
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