ZNRF1 and UBE2E2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		ZNRF1	UBE2E2
Description		zinc and ring finger 1	ubiquitin conjugating enzyme E2 E2
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Synapse	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	Protein Monoubiquitination DNA Damage Response Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 32499647 30718926 30054458 30297969 22885922 28869590 26818947 24509480 23945395) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)
Interacting Genes		14 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2V1 UBE2V2 UBE2W UBXN7	77 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B HERC5 IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF168 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBA6 UBOX5 WWP2 XIAP ZNRF1 ZNRF2
Entrez ID		84937	7325
HPRD ID		15893	06779
Ensembl ID		ENSG00000186187	ENSG00000182247
Uniprot IDs		Q8ND25	Q96LR5
PDB IDs		5YWR	1Y6L 6W9A
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Macromolecule Metabolic Process Transferase Activity Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Protein K63-linked Ubiquitination Nucleus Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Protein K6-linked Ubiquitination DNA Metabolic Process DNA Damage Response Postreplication Repair Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Cytoplasm Response To Stress Protein K6-linked Ubiquitination Immune System Process Positive Regulation Of Catabolic Process Innate Immune Response Cellular Response To Stress Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Protein Destabilization DNA Damage Response Response To Other Organism Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Defense Response
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