ZNRF1

Gene Name		zinc and ring finger 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Endosome Cytosol Membrane Cell Junction Synaptic Vesicle Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-protein Interactions		13 interactors: CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W
Entrez ID		84937
HPRD ID		15893
Ensembl ID		ENSG00000186187
Uniprot IDs		Q8ND25
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Ubiquitin-protein Transferase Activity Postreplication Repair Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Cellular Response To Oxygen Levels Nucleotide-binding Oligomerization Domain Containing Signaling Pathway DNA Repair DNA Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
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