ZNRF1

Description		zinc and ring finger 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Interacting Genes		14 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2V1 UBE2V2 UBE2W UBXN7
Entrez ID		84937
HPRD ID		15893
Ensembl ID		ENSG00000186187
Uniprot IDs		Q8ND25
PDB IDs		5YWR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Macromolecule Metabolic Process Transferase Activity Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Protein K63-linked Ubiquitination Nucleus Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Protein K6-linked Ubiquitination DNA Metabolic Process DNA Damage Response Postreplication Repair Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination
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