ZNRF1 and UBE2V2

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		ZNRF1	UBE2V2
Gene Name		zinc and ring finger 1, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2 variant 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Endosome Cytosol Membrane Cell Junction Synaptic Vesicle Membrane	Nucleus Cytoplasm UBC13-MMS2 Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Cell Proliferation Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		13 interactors: CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W	22 interactors: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 OTUB1 RNF144A RNF2 RNF8 SHPRH SIAH1 SUV39H2 TRAF2 TRIM5 UBC UBE2N XIAP ZNRF1
Entrez ID		84937	7336
HPRD ID		15893	04300
Ensembl ID		ENSG00000186187
Uniprot IDs		Q8ND25	A0M8W4 G3V113 Q15819
PDB IDs			1J74 1J7D 1ZGU 3VON 4EPO
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Ubiquitin-protein Transferase Activity Postreplication Repair Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Cellular Response To Oxygen Levels Nucleotide-binding Oligomerization Domain Containing Signaling Pathway DNA Repair DNA Metabolic Process Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of DNA Repair Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Stress Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Histone Ubiquitination Regulation Of Histone Ubiquitination Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Metabolic Process Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Immune System Process DNA Repair Protein Catabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Difference) ?			affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair mnat1 msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a
Tagcloud (Intersection) ?