ZNRF1 and UBXN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNRF1	UBXN7
Description		zinc and ring finger 1	UBX domain protein 7
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Synapse	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) IgM levels ( 28628107)
Interacting Genes		14 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2V1 UBE2V2 UBE2W UBXN7	34 interacting genes: APP CLEC19A CRX CYSRT1 DAZAP2 FAM120A FAM168A FLG IGF2BP1 IGF2BP2 IGF2BP3 LARP1 MAP3K1 MEOX1 MTDH MUL1 NEDD8 NFYC PABPC4 PAX5 PAX6 REL RNF111 RPS3 RPS3A SMURF1 TRAF6 TRIM39 TRIM62 TRIM8 UBC UBQLN1 UBQLN2 ZNRF1
Entrez ID		84937	26043
HPRD ID		15893	19396
Ensembl ID		ENSG00000186187	ENSG00000163960
Uniprot IDs		Q8ND25	O94888
PDB IDs		5YWR	1WJ4 2DAL 2DLX 5X3P 5X4L
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Macromolecule Metabolic Process Transferase Activity Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Protein K63-linked Ubiquitination Nucleus Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Protein K6-linked Ubiquitination DNA Metabolic Process DNA Damage Response Postreplication Repair Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination	Positive Regulation Of Macromolecule Metabolic Process MRNA 5'-UTR Binding Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination CRD-mediated MRNA Stabilization N6-methyladenosine-containing RNA Reader Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Base-excision Repair Macromolecule Metabolic Process Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA 3'-UTR Binding Translation Regulator Activity Cytosol Regulation Of RNA Metabolic Process Regulation Of Proteolysis MRNA Stabilization Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization NF-kappaB Complex Regulation Of Base-excision Repair Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translation Nucleus Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Protein Modification Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of MRNA Metabolic Process Cytoplasm Regulation Of RNA Stability Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process
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