UBA6 and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 37604583)
54

Data Source:
BioGRID (enzymatic study)

		UBA6	UBE2G2
Description		ubiquitin like modifier activating enzyme 6	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity FAT10 Activating Enzyme Activity Metal Ion Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		26 interacting genes: BIRC6 HMBOX1 HUWE1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2O UBE2S UBE2T UBE2Z	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		55236	7327
HPRD ID		13341	04387
Ensembl ID		ENSG00000033178	ENSG00000184787
Uniprot IDs		A0AVT1	P60604
PDB IDs		7PVN 7PYV 7SOL	2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Proteolysis Transferase Activity Protein Metabolic Process Protein Monoubiquitination ATP Binding Protein K63-linked Ubiquitination Nucleoplasm Catabolic Process Nucleotide Binding Macromolecule Metabolic Process ISG15 Transferase Activity Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein K29-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Cytosol Protein Autoubiquitination Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion HULC Complex Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Free Ubiquitin Chain Polymerization DNA Metabolic Process DNA Repair Cell Cycle Phase Transition	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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