UBA6 and JUNB

Number of citations of the paper that reports this interaction (PubMedID 31575873)
61

Data Source:
BioGRID (enzymatic study)

		UBA6	JUNB
Description		ubiquitin like modifier activating enzyme 6	JunB proto-oncogene, AP-1 transcription factor subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity FAT10 Activating Enzyme Activity Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Trophectodermal Cell Differentiation Osteoclast Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Osteoclast Differentiation Osteoblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Response To Steroid Hormone Regulation Of Cell Cycle Embryonic Process Involved In Female Pregnancy Labyrinthine Layer Blood Vessel Development Cellular Response To Calcium Ion Integrated Stress Response Signaling Regulation Of T-helper 17 Cell Differentiation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription NGF-stimulated transcription Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)
Interacting Genes		26 interacting genes: BIRC6 HMBOX1 HUWE1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2O UBE2S UBE2T UBE2Z	39 interacting genes: APLP2 ATF4 BATF BATF2 BCL6 BDNF BRCA1 DDIT3 DNMT3L EP300 ESR1 FOS FOSB FOSL1 FOSL2 HOXA7 ITCH JDP2 MAP2 MAPK14 MAPK6 MAPK8 MAPK9 NEU1 NFE2L1 NINL PKIA SAT1 SET SMAD3 SMAD4 SMURF1 TCERG1 TDG UBA6 UBE2I USP24 ZNF595 ZSWIM9
Entrez ID		55236	3726
HPRD ID		13341	01303
Ensembl ID		ENSG00000033178	ENSG00000171223
Uniprot IDs		A0AVT1	P17275 Q5U079
PDB IDs		7PVN 7PYV 7SOL
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Proteolysis Transferase Activity Protein Metabolic Process Protein Monoubiquitination ATP Binding Protein K63-linked Ubiquitination Nucleoplasm Catabolic Process Nucleotide Binding Macromolecule Metabolic Process ISG15 Transferase Activity Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein K29-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Cytosol Protein Autoubiquitination Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion HULC Complex Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Free Ubiquitin Chain Polymerization DNA Metabolic Process DNA Repair Cell Cycle Phase Transition	Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Chromatin Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signaling Cassette Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II MAP Kinase Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stem Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II R-SMAD Binding Sequence-specific Double-stranded DNA Binding Regulation Of Metabolic Process Promoter-specific Chromatin Binding
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