UBE2G2 and NDUFS4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UBE2G2	NDUFS4
Description		ubiquitin conjugating enzyme E2 G2	NADH:ubiquinone oxidoreductase subunit S4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Regulation Of Protein Phosphorylation Mitochondrial Electron Transport, NADH To Ubiquinone Brain Development Aerobic Respiration Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Response To CAMP Reactive Oxygen Species Metabolic Process Proton Transmembrane Transport
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Alanine aminotransferase levels ( 33547301)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Midgestational circulating levels of PCBs ( 28235828) Mitochondrial heteroplasmy measurement ( 33731350) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Verbal memory ( 29907492) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	2 interacting genes: APP UBE2G2
Entrez ID		7327	4724
HPRD ID		04387	04073
Ensembl ID		ENSG00000184787	ENSG00000164258
Uniprot IDs		P60604	A0A0S2Z433 O43181
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Protein Transport Axon Choice Point Recognition Regulation Of Establishment Of Protein Localization Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Response To Peptide Response To Cytokine Cellular Response To Manganese Ion Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Exit From Endoplasmic Reticulum Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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