UBE2G2 and RFFL

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2G2	RFFL
Description		ubiquitin conjugating enzyme E2 G2	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		7327	117584
HPRD ID		04387	11489
Ensembl ID		ENSG00000184787	ENSG00000092871
Uniprot IDs		P60604	Q8WZ73
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S	1Y02
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination
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