UBE2G2 and RFFL

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2G2	RFFL
Gene Name		ubiquitin-conjugating enzyme E2G 2	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Recycling Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		37 interactors: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 FARP2 HBS1L HERPUD1 KDM2A KIAA0368 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 PARK2 POLR3F RBX1 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	15 interactors: ATXN3 ATXN3L ESPL1 OTUB1 OTUB2 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UCHL5 USP28 USP5 USP7
Entrez ID		7327	117584
HPRD ID		04387	11489
Ensembl ID		ENSG00000184787	ENSG00000092871
Uniprot IDs		P60604	Q8WZ73
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD	1Y02
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Proteolysis Cellular Protein Metabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Cellular Response To Topologically Incorrect Protein Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Mitochondrial Fusion Protein Autoubiquitination Response To Stimulus Response To Unfolded Protein Regulation Of Protein Stability Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K48-linked Ubiquitination Cellular Protein Modification Process Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Repair Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Monoubiquitinated Protein Deubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization DNA Metabolic Process Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Misfolded Protein Protein K63-linked Deubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response
Tagcloud ?		alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Difference) ?		alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Intersection) ?