UBA6 and UBE2O

Number of citations of the paper that reports this interaction (PubMedID 37604583)
54

Data Source:
BioGRID (enzymatic study, enzymatic study)

		UBA6	UBE2O
Description		ubiquitin like modifier activating enzyme 6	ubiquitin conjugating enzyme E2 O
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Nucleotide Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity FAT10 Activating Enzyme Activity Metal Ion Binding	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		26 interacting genes: BIRC6 HMBOX1 HUWE1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2O UBE2S UBE2T UBE2Z	23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3
Entrez ID		55236	63893
HPRD ID		13341	10928
Ensembl ID		ENSG00000033178	ENSG00000175931
Uniprot IDs		A0AVT1	Q9C0C9
PDB IDs		7PVN 7PYV 7SOL	7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Proteolysis Transferase Activity Protein Metabolic Process Protein Monoubiquitination ATP Binding Protein K63-linked Ubiquitination Nucleoplasm Catabolic Process Nucleotide Binding Macromolecule Metabolic Process ISG15 Transferase Activity Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein K29-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Cytosol Protein Autoubiquitination Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion HULC Complex Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Free Ubiquitin Chain Polymerization DNA Metabolic Process DNA Repair Cell Cycle Phase Transition	Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane
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