UBE2G2 and CPOX

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		UBE2G2	CPOX
Name		ubiquitin conjugating enzyme E2 G2	coproporphyrinogen oxidase
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Coproporphyrinogen Oxidase Activity Structural Constituent Of Eye Lens Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Iron Ion Response To Lead Ion Response To Insecticide Response To Arsenic-containing Substance Heme O Biosynthetic Process Response To Methylmercury
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Heme biosynthesis
Diseases		None	Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Alanine aminotransferase levels ( 33547301 )	Refractive error ( 32231278 )
Novel Interactors		2 novel interactors: PSMG1 TRAPPC10	2 novel interactors: ATXN7 REEP5
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	1 interacting genes: UBE2G2
Entrez ID		7327	1371
HPRD ID		04387	00417
Ensembl ID		ENSG00000184787	ENSG00000080819
Uniprot IDs		P60604	P36551
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S	2AEX
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	None