UBE2G2 and AUP1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, cross-linking study, affinity chromatography technology)

		UBE2G2	AUP1
Description		ubiquitin conjugating enzyme E2 G2	AUP1 lipid droplet regulating VLDL assembly factor
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Response To Virus Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization ERAD Pathway Lipophagy Lipid Droplet Formation Protein Localization To Lipid Droplet
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	10 interacting genes: GRSF1 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2
Entrez ID		7327	550
HPRD ID		04387	03892
Ensembl ID		ENSG00000184787	ENSG00000115307
Uniprot IDs		P60604	Q9Y679
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S	2EKF 7LEW
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Integrin Complex Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-substrate Adhesion Signaling Receptor Activity External Side Of Plasma Membrane Cell-cell Adhesion Cell Surface Cell Adhesion Mediated By Integrin Integrin Binding Heterotypic Cell-cell Adhesion Focal Adhesion Cell Adhesion Collagen Binding Involved In Cell-matrix Adhesion Virus Receptor Activity Wound Healing, Spreading Of Epidermal Cells Basal Part Of Cell Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Response To Muscle Activity Extracellular Matrix Binding Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Formation Of Primary Germ Layer Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Angiogenesis Collagen Binding Integrin Alpha1-beta1 Complex Cell Migration Metal Ion Binding Amyloid-beta Binding Female Pregnancy Response To Activity Integrin Alpha5-beta1 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex
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