UBA6 and UBE2Z

Number of citations of the paper that reports this interaction (PMID 17597759)
66

Data Source:
BioGRID (enzymatic study, enzymatic study, two hybrid, pull down)

		UBA6	UBE2Z
Gene Name		ubiquitin-like modifier activating enzyme 6	ubiquitin-conjugating enzyme E2Z
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding ATP Binding FAT10 Activating Enzyme Activity	Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	Protein Polyubiquitination Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		12 interactors: HMBOX1 SMAD9 UBD UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2L3 UBE2L6 UBE2S UBE2T UBE2Z	31 interactors: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 PLEKHF2 PPP1CA RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA6 UBD
Entrez ID		55236	65264
HPRD ID		13341	08589
Ensembl ID			ENSG00000159202
Uniprot IDs		A0AVT1	Q9H832
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Catabolic Process Protein Metabolic Process Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Ligase Activity BMP Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Metabolic Process Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Innate Immune Response Response To Transforming Growth Factor Beta Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Protein Monoubiquitination	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Regulation Of Cell Death Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Destabilization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Endothelial Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of SMAD Protein Import Into Nucleus Apoptotic Process Negative Regulation Of Cell Proliferation SMAD Protein Complex Assembly BMP Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Programmed Cell Death Cell Death Death Regulation Of Cartilage Development Response To Stress Proteasomal Protein Catabolic Process Proteolysis Triglyceride Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Gene Expression Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Acylglycerol Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Negative Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death Metabolic Process
Tagcloud ?		adopted annotation artificial bands buffalo concise dodecyl enolase ensure estrous estrus immunoblot indicator insemination lactoperoxidase noninvasive page phases polyacrylamide precisely proteome proteomic saliva sds serotransferrin tgm3 tlr toll transducin	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Difference) ?		adopted annotation artificial bands buffalo concise dodecyl enolase ensure estrous estrus immunoblot indicator insemination lactoperoxidase noninvasive page phases polyacrylamide precisely proteome proteomic saliva sds serotransferrin tgm3 tlr toll transducin	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Intersection) ?