UBE2G2 and FARP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UBE2G2	FARP2
Description		ubiquitin conjugating enzyme E2 G2	FERM, ARH/RhoGEF and pleckstrin domain protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Cell Adhesion Signal Transduction Neuron Remodeling Rac Protein Signal Transduction Hair Cycle Process Actin Cytoskeleton Organization Osteoclast Differentiation Regulation Of Integrin Activation Cell Development Semaphorin-plexin Signaling Pathway Podosome Assembly
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Chronic lymphocytic leukemia ( 23770605 28165464) Copper levels ( 26025379) Disability (impaired activities of daily living) ( 31707593) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Triglyceride levels ( 32154731 32203549) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	9 interacting genes: BGLT3 CDH1 CDK4 CDK6 PDZK1 SRC UBC UBE2G2 YWHAG
Entrez ID		7327	9855
HPRD ID		04387	16885
Ensembl ID		ENSG00000184787	ENSG00000006607
Uniprot IDs		P60604	O94887
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Regulation Of Cellular Localization Regulation Of Protein Localization Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Transport Negative Regulation Of Cell Adhesion Positive Regulation Of Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Oxygen-containing Compound Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Negative Regulation Of TOR Signaling TOR Signaling Positive Regulation Of TOR Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Proteasomal Protein Catabolic Process Protein Kinase C Inhibitor Activity Regulation Of Establishment Of Protein Localization Extracellular Exosome Regulation Of Cell-cell Adhesion Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Cycle G2/M Phase Transition Protein Kinase Activity Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Scavenger Receptor Binding Cellular Response To Progesterone Stimulus
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