UBA6 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 17597759)
0

Data Source:
BioGRID (pull down)

		UBA6	UBE2S
Description		ubiquitin like modifier activating enzyme 6	ubiquitin conjugating enzyme E2 S
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity FAT10 Activating Enzyme Activity Metal Ion Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)
Interacting Genes		26 interacting genes: BIRC6 HMBOX1 HUWE1 JUNB LMO2 OTUB1 SMAD9 UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2O UBE2S UBE2T UBE2Z	33 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD HECTD3 HERC1 LINC00839 MDM2 NFKBIA OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7
Entrez ID		55236	27338
HPRD ID		13341	15603
Ensembl ID		ENSG00000033178	ENSG00000108106
Uniprot IDs		A0AVT1	Q16763
PDB IDs		7PVN 7PYV 7SOL	1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98 7AHF 8TAU
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Proteolysis Transferase Activity Protein Metabolic Process Protein Monoubiquitination ATP Binding Protein K63-linked Ubiquitination Nucleoplasm Catabolic Process Nucleotide Binding Macromolecule Metabolic Process ISG15 Transferase Activity Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein K29-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Cytosol Protein Autoubiquitination Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion HULC Complex Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Free Ubiquitin Chain Polymerization DNA Metabolic Process DNA Repair Cell Cycle Phase Transition	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Protein Deubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Protein Catabolic Process Protein Branched Polyubiquitination Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cysteine-type Deubiquitinase Activity Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Positive Regulation Of Mitotic Sister Chromatid Separation Cysteine-type Peptidase Activity Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reproductive Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Cell Cycle Ubiquitin Binding Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Peptidase Activity Regulation Of Mitotic Cell Cycle Phase Transition
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