MTPAP and MAP3K8

		MTPAP	MAP3K8
Description		mitochondrial poly(A) polymerase	mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding UTP Binding RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Poly(A) RNA Polymerase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitochondrial RNA 3'-end Processing MRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Mitochondrial MRNA Polyadenylation	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response
Pathways		Mitochondrial mRNA modification	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: AZI2 CALCOCO2 CLK1 DMRTB1 TBK1	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		55149	1326
HPRD ID		15097	01863
Ensembl ID		ENSG00000107951	ENSG00000107968
Uniprot IDs		Q9NVV4	P41279 Q6FG25
PDB IDs		3PQ1	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?		Dendritic Cell Proliferation Serine/threonine Protein Kinase Complex Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Protein Kinase Activity Positive Regulation Of Macroautophagy Mononuclear Cell Proliferation Kinase Activity Leukocyte Proliferation Macroautophagy Positive Regulation Of Autophagy Regulation Of Macroautophagy Xenophagy Positive Regulation Of Autophagosome Maturation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling	Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?