MTPAP and AZI2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		MTPAP	AZI2
Gene Name		mitochondrial poly(A) polymerase	5-azacytidine induced 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Intracellular Membrane-bounded Organelle	Cytoplasm
	Molecular Function	Magnesium Ion Binding UTP Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding	Protein Binding
	Biological Process	Transcription, DNA-templated MRNA Polyadenylation Histone MRNA Catabolic Process	Mitotic Cell Cycle I-kappaB Kinase/NF-kappaB Signaling Interferon-alpha Production Interferon-gamma Production Interleukin-6 Production Tumor Necrosis Factor Production T Cell Activation Dendritic Cell Proliferation Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AZI2 CALCOCO2 TBK1	11 interactors: APBA3 IKBKE MIB1 MTPAP N4BP1 ODC1 RNF31 TBK1 TICAM1 TRAF3 TXLNA
Entrez ID		55149	64343
HPRD ID		15097	10577
Ensembl ID		ENSG00000107951	ENSG00000163512
Uniprot IDs		Q9NVV4	Q9H6S1
PDB IDs		3PQ1
Enriched GO Terms of Interacting Partners?		Dendritic Cell Proliferation Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Cytokine Production Tumor Necrosis Factor Production Interferon-alpha Production Interleukin-6 Production Immune System Process Positive Regulation Of Interferon-beta Biosynthetic Process Lymphocyte Activation Leukocyte Activation Viral Process Interferon-gamma Production Cell Activation Positive Regulation Of Interferon-alpha Production Cell Proliferation Positive Regulation Of Interferon-beta Production Innate Immune Response Dendritic Cell Differentiation Regulation Of Interferon-beta Production Negative Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Defense Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 4 Signaling Pathway	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interferon-beta Production Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Immune System Process Immune System Process Response To Virus Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cytokine Biosynthetic Process Putrescine Biosynthetic Process From Ornithine Positive Regulation Of Type I Interferon Production CD40 Signaling Pathway Regulation Of Cytokine Biosynthetic Process Leukocyte Activation Protein Linear Polyubiquitination Putrescine Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Immune Response Protein Modification By Small Protein Conjugation Defense Response Defense Response To Virus Cell Activation Ornithine Metabolic Process Response To Other Organism
Tagcloud ?			activator ag azacytidine cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tbkbp1 tnfr
Tagcloud (Difference) ?			activator ag azacytidine cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tbkbp1 tnfr
Tagcloud (Intersection) ?