MTPAP and DMRTB1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		MTPAP	DMRTB1
Description		mitochondrial poly(A) polymerase	DMRT like family B with proline rich C-terminal 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding UTP Binding RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Poly(A) RNA Polymerase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Mitochondrial RNA 3'-end Processing MRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Mitochondrial MRNA Polyadenylation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation
Pathways		Mitochondrial mRNA modification
Drugs
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611)	Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)
Interacting Genes		5 interacting genes: AZI2 CALCOCO2 CLK1 DMRTB1 TBK1	90 interacting genes: ALG13 ANKHD1 BAG4 BCAS2 C1orf94 CCND3 CDKN2D CPEB2 CPSF7 CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EXOSC7 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KAT5 KIF21B KRT81 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LARP4B LENG8 MAZ MBNL1 MRPL44 MSI2 MTPAP NCKIPSD NEDD9 NIF3L1 NIP7 NXF1 PARD6G PATL1 PEF1 PKP2 PPIL3 PRMT2 PRPF39 PRPF6 PRR3 PRRC2B QKI RAMAC RBFOX1 RBFOX2 RBM14 RBM22 RBM42 RBM7 RBPMS RPA2 RPS28 SECISBP2 SF1 SF3B4 SFPQ SH3RF1 SLAIN1 SLIRP SNRPA SNRPB SNRPC SNRPN SNW1 SORBS3 SRSF2 TENT5A TEX10 TLE5 TNRC6A TOX TRNAU1AP TSG101 TXNL4A UBL5 UNKL VASP WBP4 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		55149	63948
HPRD ID		15097	16828
Ensembl ID		ENSG00000107951	ENSG00000143006
Uniprot IDs		Q9NVV4	I6L9A0 Q96MA1
PDB IDs		3PQ1
Enriched GO Terms of Interacting Partners?		Dendritic Cell Proliferation Serine/threonine Protein Kinase Complex Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Type I Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Protein Kinase Activity Positive Regulation Of Macroautophagy Mononuclear Cell Proliferation Kinase Activity Leukocyte Proliferation Macroautophagy Positive Regulation Of Autophagy Regulation Of Macroautophagy Xenophagy Positive Regulation Of Autophagosome Maturation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Nucleus MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Regulation Of MRNA Splicing, Via Spliceosome Protein Binding Regulation Of MRNA Processing U1 SnRNP Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process U2-type Prespliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process U5 SnRNP Spliceosomal Complex Assembly Negative Regulation Of Metabolic Process U2-type Precatalytic Spliceosome Negative Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Nucleolar Exosome (RNase Complex) Negative Regulation Of MRNA Metabolic Process U2-type Catalytic Step 2 Spliceosome Intermediate Filament Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Metabolic Process Cytoplasmic Exosome (RNase Complex)
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