RPL22 and SURF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPL22	SURF6
Description		ribosomal protein L22	surfeit 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Ribonucleoprotein Complex	Granular Component Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Identical Protein Binding	DNA Binding RNA Binding Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Cytoplasmic Translation Translation Alpha-beta T Cell Differentiation Translation At Presynapse	Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) TPE interval (resting) ( 32386560)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels in cardiovascular risk ( 28369058) Coagulation factor levels ( 23267103) Epithelial ovarian cancer ( 25134534) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Malaria ( 31844061) Serum alkaline phosphatase levels ( 24094242) Tonsillectomy ( 28928442 27182965) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		27 interacting genes: AP2M1 BAG4 BEND7 CALM1 CDC42 CSE1L CT45A1 DDIT4L DUX4 FGF11 FOXP1 H2BC15 IL7R MAPK14 MDM2 NSFL1C OGT PTEN SDCBP SDCBP2 SLC26A4-AS1 SNCA SRPK2 STAC3 SURF6 THAP1 ZCCHC10	6 interacting genes: ADARB1 CSNK2A1 FAM9B RBFOX2 RBM4 RPL22
Entrez ID		6146	6838
HPRD ID		01602	01714
Ensembl ID		ENSG00000116251	ENSG00000148296
Uniprot IDs		P35268	O75683
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FQ0 9G8M 9GMO	8FKP 8FKQ 8FKR 8FKS
Enriched GO Terms of Interacting Partners?		Lipid Binding Regulation Of Cell Cycle Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Presynaptic Endocytosis Positive Regulation Of Cell Population Proliferation Regulation Of Protein Localization Nucleoplasm Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Cycle Process Regulation Of Endocytosis Regulation Of Cell Population Proliferation Cellular Component Assembly Response To Cytokine Response To Peptide Regulation Of Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Transport Cytosol Response To Magnesium Ion Dendritic Spine Morphogenesis Vesicle-mediated Transport In Synapse Regulation Of Organ Growth Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Response To Type II Interferon Regulation Of Transport Regulation Of Cellular Component Size Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Communication Nucleus Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Adhesion Dendritic Spine Organization Regulation Of Synapse Organization Negative Regulation Of Protein-containing Complex Assembly Identical Protein Binding Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Localization Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process	MRNA Metabolic Process MRNA Binding Hypoglossal Nerve Morphogenesis MRNA Processing Negative Regulation Of Translational Initiation Cap-independent Translational Initiation Regulation Of Alternative MRNA Splicing, Via Spliceosome IRES-dependent Translational Initiation Of Linear MRNA Translation At Presynapse RNA Metabolic Process Regulation Of Translational Initiation Pre-mRNA Intronic Pyrimidine-rich Binding Circadian Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Negative Regulation Of Protein Metabolic Process Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of MRNA Processing Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Adenosine To Inosine Editing Negative Regulation Of Translation Positive Regulation Of Aggrephagy Regulation Of RNA Splicing TRNA-specific Adenosine Deaminase Activity RNA Processing Adenosine Deaminase Activity Nucleic Acid Metabolic Process Nucleus Deaminase Activity Nucleoplasm Rhythmic Process Negative Regulation Of Translation In Response To Stress Double-strand Break Repair Via Classical Nonhomologous End Joining Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pre-mRNA Intronic Binding Neuromuscular Process Controlling Posture Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cranial Nerve Morphogenesis Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Motor Neuron Apoptotic Process Regulation Of MRNA Metabolic Process Enteroendocrine Cell Differentiation Nucleobase-containing Compound Metabolic Process Base Conversion Or Substitution Editing Negative Regulation Of Macromolecule Metabolic Process
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