RPL22 and ZCCHC10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPL22	ZCCHC10
Description		ribosomal protein L22	zinc finger CCHC-type containing 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Heparin Binding Identical Protein Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Translation Alpha-beta T Cell Differentiation Translation At Presynapse
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) TPE interval (resting) ( 32386560)	Eyebrow thickness ( 26926045)
Interacting Genes		27 interacting genes: AP2M1 BAG4 BEND7 CALM1 CDC42 CSE1L CT45A1 DDIT4L DUX4 FGF11 FOXP1 H2BC15 IL7R MAPK14 MDM2 NSFL1C OGT PTEN SDCBP SDCBP2 SLC26A4-AS1 SNCA SRPK2 STAC3 SURF6 THAP1 ZCCHC10	55 interacting genes: ANKRD36B ARGLU1 BEND7 CAVIN1 CEP63 CEP70 COIL CTNNBL1 DAB1 DPPA2 DZIP3 EEF1A1 ELOA2 EPB41 FAM9B FRA10AC1 GKAP1 HMGXB4 IK KCTD6 KPNA3 LNX1 LUC7L2 MAB21L3 MEOX1 NUDT14 PCBP1 PIN1 PPIG PRPF3 PRPF38A PRPF40A PRR13 PSME3 PTPN3 RBM39 RPL22 SART1 SDCBP SDCBP2 SF3B2 SF3B4 SFMBT1 SIAH1 SLU7 SNIP1 SNRPD2 STAC3 STX11 TFCP2 THAP1 TP53 U2AF1 ZBTB14 ZBTB8A
Entrez ID		6146	54819
HPRD ID		01602	15699
Ensembl ID		ENSG00000116251	ENSG00000155329
Uniprot IDs		P35268	B3KVL5 B4DU89 D6R9G7 D6RHC2 G3XAM1 Q8TBK6
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Lipid Binding Regulation Of Cell Cycle Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Presynaptic Endocytosis Positive Regulation Of Cell Population Proliferation Regulation Of Protein Localization Nucleoplasm Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Cycle Process Regulation Of Endocytosis Regulation Of Cell Population Proliferation Cellular Component Assembly Response To Cytokine Response To Peptide Regulation Of Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Transport Cytosol Response To Magnesium Ion Dendritic Spine Morphogenesis Vesicle-mediated Transport In Synapse Regulation Of Organ Growth Cellular Response To Cytokine Stimulus Cellular Response To Tumor Necrosis Factor Response To Type II Interferon Regulation Of Transport Regulation Of Cellular Component Size Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Communication Nucleus Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Adhesion Dendritic Spine Organization Regulation Of Synapse Organization Negative Regulation Of Protein-containing Complex Assembly Identical Protein Binding Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Localization Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process	RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome MRNA Metabolic Process MRNA Processing Spliceosomal Complex Nucleoplasm Nuclear Speck RNA Metabolic Process RNA Processing Protein-RNA Complex Assembly Nucleus Precatalytic Spliceosome Nucleic Acid Metabolic Process RNA Binding U2-type Prespliceosome Assembly Protein Binding Identical Protein Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Macromolecule Metabolic Process U1 SnRNP Cajal Body U12-type Spliceosomal Complex U2-type Spliceosomal Complex Protein-containing Complex Assembly Pre-mRNA 3'-splice Site Binding RS Domain Binding U4/U6 X U5 Tri-snRNP Complex Cytosol Protein-containing Complex Organization MDM2/MDM4 Family Protein Binding Regulation Of Mitotic Cell Cycle Small Nuclear Ribonucleoprotein Complex MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome
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