NDUFAB1 and SMYD3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NDUFAB1	SMYD3
Gene Name		NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa	SET and MYND domain containing 3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Mitochondrial Membrane	Nucleoplasm Cytoplasm
	Molecular Function	ACP Phosphopantetheine Attachment Site Binding Involved In Fatty Acid Biosynthetic Process Fatty Acid Binding Calcium Ion Binding NADH Dehydrogenase (ubiquinone) Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Biosynthetic Process Protein Lipoylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs		NADH
Diseases
GWAS		Bipolar disorder ( 17554300)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: MRPL23 NT5C3A RBM18 SMYD3	16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557
Entrez ID		4706	64754
HPRD ID		11951	12297
Ensembl ID		ENSG00000004779	ENSG00000185420
Uniprot IDs		O14561	B3KN46 Q9H7B4
PDB IDs		2DNW	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition
Tagcloud ?		a1m abrogated alpha1 assisting binds compartment confers consuming counteract eliminate heme import innovation insult keep keratinocytes maintain microglobulin mitochondria mitochondrial protection radical recycling respiration ros severely surrounding swelling ubiquitous	blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Difference) ?		a1m abrogated alpha1 assisting binds compartment confers consuming counteract eliminate heme import innovation insult keep keratinocytes maintain microglobulin mitochondria mitochondrial protection radical recycling respiration ros severely surrounding swelling ubiquitous	blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Intersection) ?