NDUFAB1 and BBC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDUFAB1	BBC3
Description		NADH:ubiquinone oxidoreductase subunit AB1	BCL2 binding component 3
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Membrane Respiratory Chain Complex I Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex	Mitochondrion Mitochondrial Outer Membrane Lysosome Cytosol
	Molecular Function	Acyl Binding Acyl Carrier Activity Structural Molecule Activity Fatty Acid Binding Calcium Ion Binding Protein Binding Mitochondrial Large Ribosomal Subunit Binding	Protein Binding ATPase Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Aerobic Respiration Protein Lipoylation Iron-sulfur Cluster Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis [2Fe-2S] Cluster Assembly	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Determination Of Adult Lifespan Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation Protein lipoylation Mitochondrial ribosome-associated quality control	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs		NADH
Diseases
GWAS		Bipolar disorder ( 17554300)	Appendicular lean mass ( 33097823) Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829	15 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FBXL20 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		4706	27113
HPRD ID		11951	16165
Ensembl ID		ENSG00000004779	ENSG00000105327
Uniprot IDs		O14561	Q96PG8 Q9BXH1
PDB IDs		2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD 7A5H 7A5J 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF5 7OF7 7OI6 7OI7 7OI8 7OI9 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 8K2B 8PK0 8QSJ 8QU5	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP 7DVD 7P0S 7P9W 7QTX
Enriched GO Terms of Interacting Partners?			Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Mitochondrion Organization Apoptotic Signaling Pathway Mitochondrial Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Regulation Of Anoikis Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Sertoli Cell Proliferation Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Developmental Pigmentation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential DNA Damage Response Negative Regulation Of Apoptotic Signaling Pathway B Cell Apoptotic Process Calcium Ion Transport Into Cytosol Negative Regulation Of Apoptotic Process Regulation Of Developmental Pigmentation Pore Complex Regulation Of Neuron Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Death
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