AVP and CRYAB

Number of citations of the paper that reports this interaction (PubMedID 17075130)
79

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)

		AVP	CRYAB
Description		arginine vasopressin	crystallin alpha B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Dense Core Vesicle	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Water Transport Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Multicellular Organismal Response To Stress Response To Testosterone Response To Nicotine Social Behavior Intracellular Signal Transduction Vasoconstriction Maternal Behavior Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Multicellular Organismal-level Water Homeostasis Response To Electrical Stimulus Negative Regulation Of Transmission Of Nerve Impulse Renal Water Absorption Blood Vessel Diameter Maintenance Response To Peptide Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Nerve Growth Factor	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Organic anion transport by SLCO transporters Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	HSF1-dependent transactivation
Drugs
Diseases		Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS			Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)
Interacting Genes		9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17	57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		551	1410
HPRD ID		01891	00428
Ensembl ID		ENSG00000101200	ENSG00000109846
Uniprot IDs		P01185 X5DQP6	A0A024R3B9 P02511 V9HW27
PDB IDs		7BB6 7BB7 7DW9 7KH0 7R0C	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Vasopressin Vasopressin Receptor Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure Regulation Of Blood Circulation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity System Process Positive Regulation Of Systemic Arterial Blood Pressure Telencephalon Development Signal Transduction Regulation Of System Process G Protein-coupled Peptide Receptor Activity Response To Hormone Protein Kinase C Binding Positive Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Renal Water Retention Oxytocin Receptor Activity Endocytic Vesicle Regulation Of Biological Quality Transport Across Blood-brain Barrier Positive Regulation Of Multicellular Organismal Process V1A Vasopressin Receptor Binding Cerebral Cortex GABAergic Interneuron Fate Commitment Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Cellular Response To Water Deprivation Response To Water Deprivation Sperm Ejaculation Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Subpallium Development Positive Regulation Of Amacrine Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Protein-disulfide Reductase [NAD(P)H] Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Arachidonate Secretion Negative Regulation Of Urine Volume	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development
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