AVP and AVPR1A

Number of citations of the paper that reports this interaction (PMID 8106369)
25

Data Source:
HPRD (in vivo)

		AVP	AVPR1A
Gene Name		arginine vasopressin	arginine vasopressin receptor 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Activity Signal Transducer Activity Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Vasopressin Receptor Activity Protein Kinase C Binding Protein Binding Peptide Hormone Binding V1A Vasopressin Receptor Binding Peptide Binding
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Circadian Rhythm Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Sodium-independent Organic Anion Transport Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Transmembrane Transport ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Female Receptivity Grooming Behavior Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Glutamate Secretion Myotube Differentiation Calcium-mediated Signaling Telencephalon Development Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Cellular Response To Hormone Stimulus Social Behavior Positive Regulation Of Renal Sodium Excretion Cellular Response To Water Deprivation Maternal Behavior Sperm Ejaculation Penile Erection Positive Regulation Of Vasoconstriction Response To Corticosterone Negative Regulation Of Transmission Of Nerve Impulse Response To Peptide
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Aquaporin-mediated transport SLC-mediated transmembrane transport Transport of organic anions G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Transport of vitamins, nucleosides, and related molecules BMAL1:CLOCK,NPAS2 activates circadian gene expression	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Desmopressin Vasopressin Felypressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR TXNDC17	3 interactors: AVP GRK5 PRKCA
Entrez ID		551	552
HPRD ID		01891	02894
Ensembl ID		ENSG00000101200
Uniprot IDs		P01185	P37288
PDB IDs			1YTV
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Vasoconstriction Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Blood Pressure Telencephalon Development Sperm Ejaculation Blood Circulation Response To Hormone Positive Regulation Of Systemic Arterial Blood Pressure Forebrain Development Maternal Behavior Response To Peptide Insemination Positive Regulation Of Cytosolic Calcium Ion Concentration Copulation Regulation Of Renal Sodium Excretion Cellular Response To Hormone Stimulus Cytosolic Calcium Ion Homeostasis Regulation Of Excretion Response To Organic Substance Brain Development Social Behavior Head Development Organ Development Response To Organonitrogen Compound Cellular Calcium Ion Homeostasis Chemical Homeostasis Calcium Ion Homeostasis Activation Of Phospholipase C Activity Mating Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Central Nervous System Development Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Phospholipase Activity Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Response To Drug Cellular Ion Homeostasis Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Metal Ion Homeostasis Response To Steroid Hormone Cellular Chemical Homeostasis System Development Homeostatic Process Response To Estradiol	Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Phosphorylation Histone H3-T6 Phosphorylation Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Cellular Calcium Ion Homeostasis Maternal Aggressive Behavior Positive Regulation Of Cellular PH Reduction Negative Regulation Of Transmission Of Nerve Impulse Penile Erection Calcium Ion Homeostasis Phosphorylation Positive Regulation Of Glutamate Secretion Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Generation Of Precursor Metabolites And Energy Cellular Cation Homeostasis Cellular Ion Homeostasis Negative Regulation Of Female Receptivity Desmosome Assembly Hyperosmotic Salinity Response Tachykinin Receptor Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Glucose Import Positive Regulation Of Amino Acid Transport Positive Regulation Of Macrophage Differentiation Aggressive Behavior Regulation Of Transmission Of Nerve Impulse Sodium-independent Organic Anion Transport
Tagcloud ?		arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin	aldosterone bdkrb2 caucasians dbsnp functionality genotyped imply infarction infarctions leiden microrna mineralocorticoid myocardial nr3c2 raas renin rs11174811 rs13306046 rs2069591 rs5225 rs5534 smile snp snps targetscan tbxa2r thromboxane twofold vasopressin
Tagcloud (Difference) ?		arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial	aldosterone bdkrb2 caucasians dbsnp functionality genotyped imply infarction infarctions leiden microrna mineralocorticoid myocardial nr3c2 raas renin rs11174811 rs13306046 rs2069591 rs5225 rs5534 smile snp snps targetscan tbxa2r thromboxane twofold
Tagcloud (Intersection) ?		vasopressin